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Gene expression profiling in liver from control versus mutant Sox17 SHIVA fasted C57BL/6 mice

ABSTRACT: The objective of this study was to test the impact of a mutation in the Sox17 gene (SHIVA mouse) on the ability of liver to mount a transcriptional response to 24 hours of fasting.

ORGANISM(S): Mus musculus

PROVIDER: GSE38968 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA169499

REPOSITORIES: GEO

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Expression data from wild type and Sox17 heterozygous mutant uteri in early pregnancy

Project description:SOX17 activity in the uterine epithelium is essential for the implantation of mouse embryos. Previously, we demonstrated that female Sox17-heterozygous mutant mice are subfertile, and two active copies of Sox17 are required for the proper implantation of mouse embryos. To understand which implantation step is most sensitive to the Sox17 gene dosage, we comprehensively investigated the RNA transcriptomes of Sox17-heterozygous mutant mice.

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Effects of the Sox17 ∆50 mutation on SOX17 function in mouse embryonic liver development

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Transcriptional regulation of Sox17 in HUVEC

Project description:We identified Sox17 as a novel angiogenic transcription factor in the context of tumor. Our data revealed that Sox17 promotes tumor angiogenesis and tumor vessel abnormality. We found that Sox17 is specifically expressed in tumor endothelial cells within tumors. Our study elucidates a novel transcriptional regulation for tumor angiogenesis Control HUVECs vs. Sox17 knockdown HUVECs. Biological replicates: 3 control replicates, 3 transfected replicates.

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2012-07-20 | E-MTAB-970 | biostudies-arrayexpress

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