Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome wide gene expression analysis BQ.Ncf1.m1J mutated and BQ wild type mice

ABSTRACT: Whole blood and spleen tissue was collected from naïve untreated mice. We compared the gene expression profiles of naïve autoimmunity prone BQ.Ncf1.m1J mutated mice and wild type BQ mice. The samples from specific pathogen-free animal facility were collected in two sample sets (marked I and II respectively) and the germ-free facility samples (marked GF / germ free) formed the third analyzed batch. The data revealed a pronounced type I interferon signature in the Ncf1.m1J mutated mice housed in both conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE45125 | GEO | 2014/11/01

SECONDARY ACCESSION(S): PRJNA193300

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genome wide gene expression analysis BQ.Ncf1.m1J mutated and BQ wild type mice

Project description:Whole blood and spleen tissue was collected from naïve untreated mice. We compared the gene expression profiles of naïve autoimmunity prone BQ.Ncf1.m1J mutated mice and wild type BQ mice. The samples from specific pathogen-free animal facility were collected in two sample sets (marked I and II respectively) and the germ-free facility samples (marked GF / germ free) formed the third analyzed batch. The data revealed a pronounced type I interferon signature in the Ncf1.m1J mutated mice housed in both conditions. RNA was isolated and globin removal was performed for all samples. The cells were not stimulated or selected ex vivo.

2014-11-01 | E-GEOD-45125 | biostudies-arrayexpress

Commensal bacteria protect against food allergen sensitization

2014-08-15 | GSE60039 | GEO

Genome-wide gene expression analysis of BQ.Ncf1m1J mutated and BQ wild type mice during collagen induced arthritis

Project description:Whole blood and spleen tissue was collected 15 (d15) or 44 (d44) days postimmunization from mice immunized with type II collagen on day 0 and immunostimulated on day 21. We compared the gene expression profiles of disease prone BQ.Ncf1m1J mice to that in BQ wild type mice. The samples were collected in two sets (marked I and II). The results show a pronounced interferon signature and increase in inflammatory transcripts in the BQ.Ncf1m1J mice.

2017-05-10 | GSE92530 | GEO

Standardized gnotobiotic mouse model for NMR based phenotyping

Project description:Germ-free mice were inoculated with 15 representative bacterial strains selected from specific pathogen-free mice. All three microbiota mouse models were generated in two different facility sites and collected plasma sample phenotyped by NMR. 58 mice from Facility 1 (32 males and 26 females) and 59 mice from Facility 2 (29 males and 30 females) were used for analysis.

2021-06-17 | ST001847 | MetabolomicsWorkbench

Commensal bacteria protect against food allergen sensitization

Project description:Analysis of colonic epithelial cell gene expression in germ-free, Bacteroides uniformis-colonized, and Clostridia-colonized gnotobiotic mice. Bacteria were isolated from our SPF mouse facility and were used to selectively colonize germ-free mice. Germ free mice were left germ free or were colonized with Bacteroides uniformis or a consortium of Clostridia. Total RNA was extraced from colonic epithelial cells.

2014-08-15 | E-GEOD-60039 | biostudies-arrayexpress

RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice

Project description:This study aimed to quantify and compare the mRNA abundance of all major XPGs in liver and intestine between conventional (CV) and germ-free (GF) mice using RNA-Seq. The CV RNA-Seq data were previously uploaded to GEO database by the same research group (GSE79848). All CV and GF mice were age-matched, and were analyzed under the same conditions (diet, water, bedding, and animal facility).

2017-08-30 | GSE102867 | GEO

Small RNA sequencing of lipoproteins (HDL) obtained from germ-free mice and facility matched specific-pathogen free mice.

Project description:Small RNA sequencing of lipoproteins (HDL) obtained from germ-free mice and facility matched specific-pathogen free mice.

| PRJNA852523 | ENA

Delayed gut colonization changes future insulin resistance and hepatic gene expression but not adiposity in high-fat diet induced obese mice

Project description:Since the first findings that germ-free mice appeared resistant to diet-induced obesity, an increasing number of studies have emphasized the role of the gut microbiota as a core regulator of host weight gain and metabolism. However, several studies have not been replicable and conflicting results have left the discussion surrounding causality elusive. Specifically, the importance of early microbial dysbiosis in later development of obesity and metabolic disorders has been a subject of debate. Male Swiss Webster mice raised under germ-free conditions were introduced to a specific-pathogen-free (SPF) facility for microbial colonization at 1 week (1W) and 3 weeks (3W) of age. They were compared with control animals (SPF) with a complete gut microbiota from birth. Liver RNAseq of 7 week old animals showed differential gene expression between the groups

2024-04-01 | GSE249397 | GEO

Project description:germ-free mice gut microbiota

| PRJNA1004409 | ENA

Mus musculus

Project description:Genome wide gene expression analysis BQ.Ncf1.m1J mutated and BQ wild type mice

| PRJNA193300 | ENA