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To identify ATFS-1 target genes during mitochondrial stress

ABSTRACT: To better understand genome coordination and OXPHOS recovery during mitochondrial dysfunction, we examined ATFS-1, a transcription factor that regulates mitochondria-to nuclear communication during the mitochondrial UPR, via ChIP-sequencing.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE63803 | GEO | 2015/03/03

SECONDARY ACCESSION(S): PRJNA269110

REPOSITORIES: GEO

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To identify ATFS-1 target genes during mitochondrial stress

Project description:To better understand genome coordination and OXPHOS recovery during mitochondrial dysfunction, we examined ATFS-1, a transcription factor that regulates mitochondria-to nuclear communication during the mitochondrial UPR, via ChIP-sequencing. Wildtype worms treated spg-7(RNAi) are analyzed in the presence and absence of ATFS-1 antibody to identify ATFS-1 targets. Individual samples were analyzed. Wildtype worms treated spg-7(RNAi) in the absence of antibody is used as a control.

2015-03-03 | E-GEOD-63803 | biostudies-arrayexpress

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ATFS-1 mediates a protective transcription program during mitochondrial stress

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