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Transcriptional changes in Atlantic salmon (Salmo salar) after embryonic exposure to road salt (NaCl)

ABSTRACT: The present study aimed to identify the persistent molecular changes occurring in Atlantic Salmon salmon (Salmo salar) eggs after 24h exposure to high concentrations (5000 mg/L) of road salt at fertilization.

ORGANISM(S): Salmo salar salmonid fish

PROVIDER: GSE71714 | GEO | 2015/08/05

SECONDARY ACCESSION(S): PRJNA291878

REPOSITORIES: GEO

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Transcriptional changes in Atlantic salmon (Salmo salar) after embryonic exposure to road salt (NaCl)

Project description:The present study aimed to identify the persistent molecular changes occurring in Atlantic Salmon salmon (Salmo salar) eggs after 24h exposure to high concentrations (5000 mg/L) of road salt at fertilization. Atlantic Salmon (Salmo salar) eggs after fertilization were exposed to high concentrations (5000 mg/L) of road salt for 24 h and used for gene expression analysis.

2015-08-05 | E-GEOD-71714 | biostudies-arrayexpress

The farmed Atlantic salmon (Salmo salar) skin-mucus proteome

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Project description:An effective and economical vaccine against the Piscirickettsia salmonis pathogen is needed for sustainable salmon farming and to reduce disease-related economic losses. Consequently, the aquaculture industry urgently needs to investigate efficient prophylactic measures. Three protein-based vaccine prototypes against Piscirickettsia salmonis were prepared from a highly pathogenic Chilean isolate. Only one vaccine effectively protected Atlantic salmon (Salmo salar), in correlation with the induction of Piscirickettsia-specific IgM antibodies and a high induction of transcripts encoding pro-inflammatory cytokines (i.e. Il-1β and TNF-α). In addition, we studied the proteome fraction protein of P. salmonis strain Austral-005 using multidimensional protein identification technology. The analyzes identified 87 proteins of different subcellular origins, such as the cytoplasmic and membrane compartment, where many of them have virulence functions. The other two prototypes activated only the innate immune responses, but did not protect Salmo salar against Piscirickettsia salmonis. These results suggest that the knowledge of the formulation of vaccines based on P. salmonis proteins is useful as an effective therapy, this demonstrates the importance of the different research tools to improve the study of the different immune responses, resistance to diseases in the Atlantic salmon. We suggest that this vaccine can help prevent widespread infection by P. salmonis, in addition to being able to be used as a booster after a primary vaccine to maintain high levels of circulating protective antibodies, greatly helping to reduce the economic losses caused by the pathogen.

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Salmo salar

Project description:Transcriptional changes in Atlantic salmon (Salmo salar) after embryonic exposure to road salt (NaCl)

| PRJNA291878 | ENA

Combined hepatic transcriptional effects of gamma radiation and depleted uranium on Atlantic salmon (Salmo salar)

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Diel and circadian analysis of clock gene transcripts in central and peripheral tissues in the Atlantic salmon (Salmo salar)

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Comparative transcriptomics of Atlantic Salmo salar, chum Onchorhynchus keta and pink salmon O. gorbuscha responding to salmon lice Lepeophtheirus salmonis infections

Project description:The present work characterizes the response of co-habited Atlantic (Salmo salar), chum (Oncorhynchus keta) and pink salmon (Oncorhynchus gorbuscha) to sea lice infections. Atlantic and pink salmon anterior kidney samples were profiled at three time points over nine days after the start of an experimental infection. Chum salmon anterior kidney was profiled at day six post infection only. All three species were also profiled at six days post exposure for skin responses of the pectoral fin, typically associated with lice infection.

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