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Expression data from undifferentiated and differentiated human ES cells

ABSTRACT: GCNF controls the level of Oct4 expression during ES cell differentiation and early mouse embryonic development. GCNF was overexpressed in H9 human ES cells using Tet-On Inducible system. mRNA microarray analysis demonstrated that overexpression of GCNF globally regulates gene expression in undifferentiated and differentiated hES cells. Within altered genes, GCNF down-regulated 36% of the genes, and up-regulated 64% of the genes in undifferentiated hES cells. In addition, GCNF also showed a regulatory gene pattern that is different from RA treatment during hES cell differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE76282 | GEO | 2016/12/23

SECONDARY ACCESSION(S): PRJNA306784

REPOSITORIES: GEO

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