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Comparison of wt, Krt18+/- and Krt18-/- non-tumorous liver tissues at the age of 3, 6 and 12 months [gene expression]

ABSTRACT: Analysis of the different genotypes of non-tumorous mouse livers in 3 different ages revealed more genetic alterations in Krt18-/- and Krt18+/- compared to wt livers. This speaks in favor of a higher genomic instability being causally related to K-deficiency and aging, even at a preneoplastic stage.

ORGANISM(S): Mus musculus

PROVIDER: GSE81052 | GEO | 2016/05/04

SECONDARY ACCESSION(S): PRJNA320387

REPOSITORIES: GEO

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Comparison of wt, krt18+/- and krt18-/- non-tumorous liver tissues at the age of 12 and 18 months [aCGH]

Project description:Analysis of the different genotypes of non-tumorous mouse livers in 3 different ages revealed more genetic alterations in Krt18-/- and Krt18+/- compared to wt livers. This speaks in favor of a higher genomic instability being causally related to K-deficiency and aging, even at a preneoplastic stage.

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