Project description:Analysis of the different genotypes of non-tumorous mouse livers in 3 different ages revealed more genetic alterations in Krt18-/- and Krt18+/- compared to wt livers. This speaks in favor of a higher genomic instability being causally related to K-deficiency and aging, even at a preneoplastic stage.
Project description:Analysis of the different genotypes of non-tumorous mouse livers in 3 different ages revealed more genetic alterations in Krt18-/- and Krt18+/- compared to wt livers. This speaks in favor of a higher genomic instability being causally related to K-deficiency and aging, even at a preneoplastic stage.
Project description:This SuperSeries is composed of the following subset Series: GSE23352: Whole-genome gene expression profiles of non-tumorous human lung tissues: Laval set GSE23529: Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set GSE23545: Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set Refer to individual Series
Project description:Analysis of the different genotype tumors revealed enhanced chromosomal aberrations in all tumors. The most chromosomal aberrations were found in the krt18-/- tumors. Two-condition experiment: wt (non-affected) liver tissue vs. wt tumor / krt18+/-tumor / krt18-/- tumor
Project description:We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Project description:We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Project description:We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Project description:We compared the proteomes of FFPE and fresh frozen tissues (both tumorous and non-tumorous) from 16 prostate cancer patients using pressure cycling technology and SWATH-MS.
Project description:KrasG12D mutation and Mdm2 loss in the liver (LiKM) accelerated liver carcinogenesis in mice, compared with LiK (KrasG12D mutation in the liver) mice. Acyclic retinoid (ACR) diet suppressed tumor development in LiKM mice. The goal of RNA-seq of non-tumorous liver tissues is to identifiy the effect of ACR diet on the transcriptomic profile of the liver and clarify the mechamism of ACR-mediated tumor suppression in LiKM mice.