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Plasma and B cells from mice treated with GSK-LSD1

ABSTRACT: We treated mice daily with the GSK-LSD1 or vehicle for 21 days. B and plasma cells were isolated by FACS and RNA-seq performed. Pathway analysis showed that MYC targets, Unfolded protein response, TNFalpha signaling, STAT3, STAT5 and other signaling pathways were significantly altered.

ORGANISM(S): Mus musculus

PROVIDER: GSE85596 | GEO | 2017/08/12

SECONDARY ACCESSION(S): PRJNA338916

REPOSITORIES: GEO

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Human small intestinal organoids grown with a specific protocol to enrich for Paneth cells were treated with an inhbitor (GSK-LSD1) for the epigenetic modulator LSD1.

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