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Gene expression in rat striatum following carbon monoxide poisoning and hypoxic hypoxia

ABSTRACT: We have proposed the existence of a threshold for brain damage, in terms of hydroxyl radical production in rat striatum, between poisoning of carbon monoxide (CO) at 1000 ppm and 3000 ppm, where blood CO-hemoglobin levels reach approximately 50% and over 70%, respectively. To search for factors involved in brain damage, we examined the effects of air, 1000 ppm CO, 3000 ppm CO and 5% O2 (hypoxic conditions comparable with those by 3000 ppm CO) on gene expression in rat striatum, using microarray analysis.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE94780 | GEO | 2017/04/03

SECONDARY ACCESSION(S): PRJNA374034

REPOSITORIES: GEO

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