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Dose response of carbon monoxide treatment of M. tuberculosis

ABSTRACT: Transcriptional profiling of M. tuberculosis growing in log phase treated with various concentrations of carbon monoxide versus untreated controls Keywords: Dose response Two condition experiment, CO treated cells at 2000, 200 and 20 ppm versus untreated controls. Biological replicates: 2 replicates per dose, 1 array per replicate

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: Michael Shiloh

PROVIDER: E-GEOD-11095 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.

Shiloh Michael U MU Manzanillo Paolo P Cox Jeffery S JS

Cell host & microbe 20080501 5

Mycobacterium tuberculosis (MTB) expresses a set of genes known as the dormancy regulon in vivo. These genes are expressed in vitro in response to nitric oxide (NO) or hypoxia, conditions used to model MTB persistence in latent infection. Although NO, a macrophage product that inhibits respiration, and hypoxia are likely triggers in vivo, additional cues could activate the dormancy regulon during infection. Here, we show that MTB infection stimulates expression of heme oxygenase (HO-1) by macrop ...[more]

PMID: 18474359

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