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Paramutation of natural epialleles in tomato

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Solanum lycopersicum x Solanum pennellii Solanum pennellii Solanum lycopersicum Solanum pimpinellifolium

PROVIDER: GSE97247 | GEO | 2017/08/18

SECONDARY ACCESSION(S): PRJNA381070

REPOSITORIES: GEO

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Paramutation-like features of multiple natural epialleles in tomato.

Project description:BackgroundFreakish and rare or the tip of the iceberg? Both phrases have been used to refer to paramutation, an epigenetic drive that contravenes Mendel's first law of segregation. Although its underlying mechanisms are beginning to unravel, its understanding relies only on a few examples that may involve transgenes or artificially generated epialleles.ResultsBy using DNA methylation of introgression lines as an indication of past paramutation, we reveal that the paramutation-like properties of the H06 locus in hybrids of Solanum lycopersicum and a range of tomato relatives and cultivars depend on the timing of sRNA production and conform to an RNA-directed mechanism. In addition, by scanning the methylomes of tomato introgression lines for shared regions of differential methylation that are absent in the S. lycopersicum parent, we identify thousands of candidate regions for paramutation-like behaviour. The methylation patterns for a subset of these regions segregate with non Mendelian ratios, consistent with secondary paramutation-like interactions to variable extents depending on the locus.ConclusionTogether these results demonstrate that paramutation-like epigenetic interactions are common for natural epialleles in tomato, but vary in timing and penetrance.

| S-EPMC5859443 | biostudies-literature

Paramutation of natural epialleles in tomato [sRNA]

Project description:By using DNA methylation of introgression lines as a marker of past paramutation, we characterise in details the paramutation of the \textit{H06} locus in crosses between Solanum lycopersicum and a range of tomato relatives and cultivars. Paramutation of H06 depends on the timing of sRNA production and conforms to the RNA-directed model of paramutation. By scanning the methylomes of tomato introgression lines for shared regions of differential methylation, thousands of candidate regions for paramutation are identified. Analysing the segregation of the methylation patterns for a subset of these regions shows variations in the penetrance of paramutation-like interactions.

2017-08-18 | GSE97206 | GEO

Paramutation of natural epialleles in tomato [BiSulfite-seq]

2017-08-18 | GSE97192 | GEO

Paramutation of natural epialleles in tomato

Project description:Paramutation of natural epialleles in tomato

| PRJNA381070 | ENA