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Transcriptional analysis of Leishmania major methotrexate resistant strains using full-genome DNA microarrays

ABSTRACT: Transcriptional analysis of the drug resistant strain L. major MTX60.4 compared to the wild-type strain LV39 The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L.major LV39 Keywords: drug resistance

ORGANISM(S): Leishmania major Leishmania infantum

PROVIDER: GSE9948 | GEO | 2008/08/01

SECONDARY ACCESSION(S): PRJNA105077

REPOSITORIES: GEO

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Transcriptional analysis of Leishmania infantum methotrexate resistant strains using full-genome DNA microarrays

2008-08-01 | GSE9947 | GEO

Transcriptional analysis of Leishmania major methotrexate resistant strains using full-genome DNA microarrays

Project description:Transcriptional analysis of the drug resistant strain L. major MTX60.4 compared to the wild-type strain LV39 The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L.major LV39 Keywords: drug resistance Two-condition experiment, resistant strain MTX60.4 vs wild-type LV39. Four biological replicates for each strain, independently grown and harvested. One replicate per array

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Transcriptional analysis of Leishmania infantum methotrexate resistant strains using full-genome DNA microarrays

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Comparative Genomic Hybridization of Leishmania major methotrexate resistant strains vs wild-type LV39

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Project description:The aim of the experiment is to detect any gene expression modulation in an antimony resistant L.infantum Sb2000.1 strain compared to an antimony sensitive L.infantum WT strain. We want to identify the modulated genes associated with an antimony resistant phenotype. The Sb2000.1 resistant strain used is about 1000 times more resistant to SbIII than the WT sensitive strain. The full-genome DNA microarrays includes one 70-oligonucleotide probe for each gene of L. infantum. Keywords: drug resistance

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Methotrexate resistant Leishmania strains

Project description:This SuperSeries is composed of the SubSeries listed below.

2008-08-01 | GSE9949 | GEO

Transcriptional analysis of wild-type Leishmania species between both stages using full-genome DNA microarrays

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