Metabolomics

Dataset Information

0

GNPS - Multi-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease

ABSTRACT: Simultaneous extraction of proteins and lipids from human frontal cortex and cerebellum brain tissue was performed using the MPLEx procedure for both control and Alzheimer's disease patients. The isolated proteins were then reduced, alkylated, tryptically digested and evaluated with LC-IMS-MS. The proteomics data was matched to an AMT tag database created from pooled and fractionated samples for peptide identification. The extracted lipids were assessed with both LC-MS/MS and LC-IMS-MS to study isomer differences. The lipids were identified using LIQUID software.

INSTRUMENT(S): In-house built IMS-MS with Agilent TOF MS, Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Erin S. Baker  

PROVIDER: MSV000092627 | GNPS | Tue Aug 08 17:08:00 BST 2023

REPOSITORIES: GNPS

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1
altmetric image

Publications

Alzheimer's disease (AD) is a neurodegenerative disease with a complex etiology influenced by confounding factors such as genetic polymorphisms, age, sex, and race. Traditionally, AD research has not prioritized these influences, resulting in dramatically skewed cohorts such as three times the number of Apolipoprotein E (APOE) ε4-allele carriers in AD relative to healthy cohorts. Thus, the resulting molecular changes in AD have previously been complicated by the influence of apolipoprotein E dis  ...[more]

Similar Datasets

Proteomics Multi-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease
2023-08-08 | MSV000092627 | MassIVE
Transcriptomics Cerebellum Alzheimer's Disease
2010-06-11 | E-GEOD-6777 | biostudies-arrayexpress
Transcriptomics Cerebellum Control (Alzheimer's disease control)
2010-06-11 | E-GEOD-6778 | biostudies-arrayexpress
Genomics,Multiomics Homo sapiens
| PRJNA104191 | ENA
Transcriptomics Transcription profiling by high throughput sequencing of 7 tissues of maize inbred line Zheng 58
2013-01-26 | E-MTAB-964 | biostudies-arrayexpress
Transcriptomics Temporal Cortex Alzheimer's Disease
2010-06-11 | E-GEOD-6775 | biostudies-arrayexpress
Transcriptomics Temporal Cortex Control (Alzheimer's disease control)
2010-06-11 | E-GEOD-6774 | biostudies-arrayexpress
Transcriptomics Temporal lobe epilepsy and Alzheimer's disease
2007-01-23 | E-GEOD-6834 | biostudies-arrayexpress
Genomics,Multiomics Homo sapiens
| PRJNA104193 | ENA
Transcriptomics Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function
2012-02-14 | E-GEOD-35709 | biostudies-arrayexpress