Proteomics

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Proteomics reveals the ribosome signaling pathway promoting prostate cancer progression and correlating with poor prognosis

ABSTRACT: Through digital rectal examinations and routine prostate-specific antigen (PSA) screening, early treatment of prostate cancer has become possible. However, prostate cancer is a complex and heterogeneous disease. In many patients, cancer cells can invade adjacent tissues and metastasize to other tissues, resulting in difficultly to cure. For the treatment of primary and metastatic prostate cancer, a significant problem is how to improve its survival time. Here, we collect 7 untreated primary and metastatic prostate cancer and 6 benign prostate hyperplasia samples under ultrasound guidance by experienced radiologists using the 18-G needle. Through mass spectrometry, we have completely depicted the protein atlas of primary and metastatic prostate cancer and benign prostate hyperplasia. Through bioinformatics analysis, experimental verification, and combined clinical data, we discover that the ribosome signaling pathway promotes the progression of prostate cancer and is associated with a poor prognosis. Among them, Mrpl1, Mrpl4, and Mrpl16 may be biomolecular markers for diagnosis and prognosis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jiangbei Yuan  

PROVIDER: PXD028211 | iProX | Sun Sep 05 00:00:00 BST 2021

REPOSITORIES: iProX

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Radiogenomic analysis of ultrasound phenotypic features coupled to proteomes predicts metastatic risk in primary prostate cancer.

Fu Qihuan Q   Luo Li L   Hong Ruixia R   Zhou Hang H   Xu Xinzhi X   Feng Yujie Y   Huang Kaifeng K   Wan Yujie Y   Li Ying Y   Gong Jiaqi J   Le Xingyan X   Liu Xiu X   Wang Na N   Yuan Jiangbei J   Li Fang F  

BMC cancer 20240304 1

<h4>Background</h4>Primary prostate cancer with metastasis has a poor prognosis, so assessing its risk of metastasis is essential.<h4>Methods</h4>This study combined comprehensive ultrasound features with tissue proteomic analysis to obtain biomarkers and practical diagnostic image features that signify prostate cancer metastasis.<h4>Results</h4>In this study, 17 ultrasound image features of benign prostatic hyperplasia (BPH), primary prostate cancer without metastasis (PPCWOM), and primary pros  ...[more]

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