Proteomics

Dataset Information

0

Proteomics of human TB and MAC-LD granulomas


ABSTRACT: FFPE of TB or MAC-LD granulomatous lesions from surgically resection were dissected and subcompartments of granulomas were separately collected. Tryptic peptides were subjected to a Q Exactive and proteomic data were acquired.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Shintaro Seto 

PROVIDER: PXD014086 | JPOST Repository | Fri Nov 19 00:00:00 GMT 2021

REPOSITORIES: jPOST

Dataset's files

Source:
Action DRS
LFQ%20data%20set%20(total).txt Txt
MAC_caseum_01.raw Raw
MAC_caseum_02.raw Raw
MAC_caseum_03.raw Raw
MAC_cell_01.raw Raw
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Publications

Proteomic Profiling Reveals the Architecture of Granulomatous Lesions Caused by Tuberculosis and <i>Mycobacterium avium</i> Complex Lung Disease.

Seto Shintaro S   Morimoto Kozo K   Yoshida Tsutomu T   Hiramatsu Miyako M   Hijikata Minako M   Nagata Toshi T   Kikuchi Fumihito F   Shiraishi Yuji Y   Kurashima Atsuyuki A   Keicho Naoto N  

Frontiers in microbiology 20200117


Tuberculosis (TB) and <i>Mycobacterium avium</i> complex lung disease (MAC-LD) are both characterized pathologically by granuloma lesions, which are typically composed of a necrotic caseum at the center surrounded by fibrotic cells and lymphocytes. Although the histological characterization of TB and MAC-LD granulomas has been well-documented, their molecular signatures have not been fully evaluated. In this research we applied mass spectrometry-based proteomics combined with laser microdissecti  ...[more]

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