Dataset Information

So_Kinase_Networks_in_TRAIL_induced_apoptosis

ABSTRACT: This submission consists of the mass spectrometry raw files for the manuscript by So et al. (Kinase Networks in TRAIL induced apoptosis). This submission contains files for the data presented as supplementary tables 5 (interaction network of 104 protein kinases in DLD-1 cells) acquired on a QSTAR Elite and table 7 (global phosphorylation analysis of TRAIL-stimulated DLD-1 cells) acquired on an LTQ Orbitrap. See the README file within "Methods" and the accompanying File description.

INSTRUMENT(S): QSTAR Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Karen Colwill

PROVIDER: MSV000078989 | MassIVE | Fri Jan 09 13:17:00 GMT 2015

REPOSITORIES: MassIVE

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Publications

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

So Jonathan J Pasculescu Adrian A Dai Anna Y AY Williton Kelly K James Andrew A Nguyen Vivian V Creixell Pau P Schoof Erwin M EM Sinclair John J Barrios-Rodiles Miriam M Gu Jun J Krizus Aldis A Williams Ryan R Olhovsky Marina M Dennis James W JW Wrana Jeffrey L JL Linding Rune R Jorgensen Claus C Pawson Tony T Colwill Karen K

Science signaling 20150407 371

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells rather than in normal cells. The acquisition of resistance in cells exposed to TRAIL or its mimics limits their clinical efficacy. Because kinases are intimately involved in the regulation of apoptosis, we systematically characterized kinases involved in TRAIL signaling. Using RNA interference (RNAi) loss-of-function and cD ...[more]

PMID: 25852190

Dataset Information

So_Kinase_Networks_in_TRAIL_induced_apoptosis

Dataset's files

Publications

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

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