Proteomics

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Gingras_Mui_E4orf4_interactions_P107_V5

ABSTRACT: This submission includes the mass spectrometry data for the manuscript by Mui et al. (E4orf4 interactome). This submission contains 16 files for E4orf4 WT or mutant interactions from HEK293 cells, acquired on LTQ Orbitrap Velos and LTQ Orbitrap Elite. See the README file within "Methods and Protocols" and the accompanying File description and peptide and interaction identification results.

INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap Elite

ORGANISM(S): Human Adenovirus 5 (ncbitaxon:28285) Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras 

PROVIDER: MSV000079082 | MassIVE | Fri Mar 20 09:20:00 GMT 2015

SECONDARY ACCESSION(S): PXD001956

REPOSITORIES: MassIVE

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Publications

The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway.

Mui Melissa Z MZ   Zhou Yiwang Y   Blanchette Paola P   Chughtai Naila N   Knight Jennifer F JF   Gruosso Tina T   Papadakis Andreas I AI   Huang Sidong S   Park Morag M   Gingras Anne-Claude AC   Branton Philip E PE  

Journal of virology 20150617 17

<h4>Unlabelled</h4>When expressed alone at high levels, the human adenovirus E4orf4 protein exhibits tumor cell-specific p53-independent toxicity. A major E4orf4 target is the B55 class of PP2A regulatory subunits, and we have shown recently that binding of E4orf4 inhibits PP2A(B55) phosphatase activity in a dose-dependent fashion by preventing access of substrates (M. Z. Mui et al., PLoS Pathog 9:e1003742, 2013, http://dx.doi.org/10.1371/journal.ppat.1003742). While interaction with B55 subunit  ...[more]

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