Alveolar Injury and Regeneration Following Deletion of ABCA3
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA401769
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Charles Ansong
PROVIDER: MSV000081473 | MassIVE | Tue Aug 22 13:39:00 BST 2017
REPOSITORIES: MassIVE
Publications
Alveolar injury and regeneration following deletion of ABCA3.
Rindler Tara N TN Stockman Courtney A CA Filuta Alyssa L AL Brown Kari M KM Snowball John M JM Zhou Wenjia W Veldhuizen Ruud R Zink Erika M EM Dautel Sydney E SE Clair Geremy G Ansong Charles C Xu Yan Y Bridges James P JP Whitsett Jeffrey A JA
JCI insight 20171221 24
Adaptation to air breathing after birth is dependent upon the synthesis and secretion of pulmonary surfactant by alveolar type 2 (AT2) cells. Surfactant, a complex mixture of phospholipids and proteins, is secreted into the alveolus, where it reduces collapsing forces at the air-liquid interface to maintain lung volumes during the ventilatory cycle. ABCA3, an ATP-dependent Walker domain containing transport protein, is required for surfactant synthesis and lung function at birth. Mutations in AB ...[more]
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