Proteomics

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NCI60 proteome by PCT-SWATH - Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines

ABSTRACT: We obtained quantitative analysis of the NCI-60 cell panels using pressure cycling technology (PCT) and SWATH-MS. Each cell was analyzed in duplicate. The data were analyzed using a cell line SWATH assay library and OpenSWATH, followed by SWATH-expert refinement.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Ruedi Aebersold  

PROVIDER: MSV000085848 | MassIVE | Wed Jul 29 14:53:00 BST 2020

SECONDARY ACCESSION(S): PXD003539

REPOSITORIES: MassIVE

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Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.

Guo Tiannan T   Luna Augustin A   Rajapakse Vinodh N VN   Koh Ching Chiek CC   Wu Zhicheng Z   Liu Wei W   Sun Yaoting Y   Gao Huanhuan H   Menden Michael P MP   Xu Chao C   Calzone Laurence L   Martignetti Loredana L   Auwerx Chiara C   Buljan Marija M   Banaei-Esfahani Amir A   Ori Alessandro A   Iskar Murat M   Gillet Ludovic L   Bi Ran R   Zhang Jiangnan J   Zhang Huanhuan H   Yu Chenhuan C   Zhong Qing Q   Varma Sudhir S   Schmitt Uwe U   Qiu Peng P   Zhang Qiushi Q   Zhu Yi Y   Wild Peter J PJ   Garnett Mathew J MJ   Bork Peer P   Beck Martin M   Liu Kexin K   Saez-Rodriguez Julio J   Elloumi Fathi F   Reinhold William C WC   Sander Chris C   Pommier Yves Y   Aebersold Ruedi R  

iScience 20191031

Here we describe a proteomic data resource for the NCI-60 cell lines generated by pressure cycling technology and SWATH mass spectrometry. We developed the DIA-expert software to curate and visualize the SWATH data, leading to reproducible detection of over 3,100 SwissProt proteotypic proteins and systematic quantification of pathway activities. Stoichiometric relationships of interacting proteins for DNA replication, repair, the chromatin remodeling NuRD complex, β-catenin, RNA metabolism, and  ...[more]

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