Proteomics

Dataset Information

0

DDA files of human cancer cells for the NCI-60 SWATH project PXD003539


ABSTRACT: This is the raw files for the DDA library used for intepreting the NCI-60 SWATH project PXD003539

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Cell Line Cell

DISEASE(S): Lung Cancer,Colon Cancer,Acute Leukemia,Prostate Cancer,Brain Cancer,Kidney Cancer,Malignant Neoplasm Of Ovary,Breast Cancer

SUBMITTER: Tiannan Guo  

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD009597 | Pride | 2019-10-21

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
consensus.splib Other
guot_J130320_001.wiff Wiff
guot_J130320_001.wiff.scan Wiff
guot_J130320_002.wiff Wiff
guot_J130320_002.wiff.scan Wiff
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Publications

Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.

Guo Tiannan T   Luna Augustin A   Rajapakse Vinodh N VN   Koh Ching Chiek CC   Wu Zhicheng Z   Liu Wei W   Sun Yaoting Y   Gao Huanhuan H   Menden Michael P MP   Xu Chao C   Calzone Laurence L   Martignetti Loredana L   Auwerx Chiara C   Buljan Marija M   Banaei-Esfahani Amir A   Ori Alessandro A   Iskar Murat M   Gillet Ludovic L   Bi Ran R   Zhang Jiangnan J   Zhang Huanhuan H   Yu Chenhuan C   Zhong Qing Q   Varma Sudhir S   Schmitt Uwe U   Qiu Peng P   Zhang Qiushi Q   Zhu Yi Y   Wild Peter J PJ   Garnett Mathew J MJ   Bork Peer P   Beck Martin M   Liu Kexin K   Saez-Rodriguez Julio J   Elloumi Fathi F   Reinhold William C WC   Sander Chris C   Pommier Yves Y   Aebersold Ruedi R  

iScience 20191031


Here we describe a proteomic data resource for the NCI-60 cell lines generated by pressure cycling technology and SWATH mass spectrometry. We developed the DIA-expert software to curate and visualize the SWATH data, leading to reproducible detection of over 3,100 SwissProt proteotypic proteins and systematic quantification of pathway activities. Stoichiometric relationships of interacting proteins for DNA replication, repair, the chromatin remodeling NuRD complex, β-catenin, RNA metabolism, and  ...[more]

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