Proteomics

Dataset Information

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NCI60 proteome by PCT-SWATH - Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines

ABSTRACT: We obtained quantitative analysis of the NCI-60 cell panels using pressure cycling technology (PCT) and SWATH-MS. Each cell was analyzed in duplicate. The data were analyzed using a cell line SWATH assay library and OpenSWATH, followed by SWATH-expert refinement.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Melanocyte Of Skin, Follicle Cell, Blood Cell, Epithelial Cell Of Prostate, Cerebral Cortex Glial Cell, Renal Cortical Epithelial Cell, Whole Body, Colon Epithelial Cell, Mammary Gland Epithelial Cell, Lung Endothelial Cell

DISEASE(S): Prostate Adenocarcinoma,Colon Cancer,Acute Leukemia,Lung Mixed Small Cell And Squamous Cell Carcinoma,Brain Cancer,Malignant Neoplasm Of Ovary,Renal Cell Carcinoma,Breast Cancer,Skin Amelanotic Melanoma

SUBMITTER: Tiannan Guo  

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD003539 | Pride | 2020-06-01

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
ConvertTSVToTraML.TraML Other
ConvertTSVToTraML.csv Csv
feature_alignment_requant_matrix.tsv Tabular
guot_L130610_003_SW.wiff Wiff
guot_L130610_003_SW.wiff.mtd Wiff
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Publications

Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.

Guo Tiannan T   Luna Augustin A   Rajapakse Vinodh N VN   Koh Ching Chiek CC   Wu Zhicheng Z   Liu Wei W   Sun Yaoting Y   Gao Huanhuan H   Menden Michael P MP   Xu Chao C   Calzone Laurence L   Martignetti Loredana L   Auwerx Chiara C   Buljan Marija M   Banaei-Esfahani Amir A   Ori Alessandro A   Iskar Murat M   Gillet Ludovic L   Bi Ran R   Zhang Jiangnan J   Zhang Huanhuan H   Yu Chenhuan C   Zhong Qing Q   Varma Sudhir S   Schmitt Uwe U   Qiu Peng P   Zhang Qiushi Q   Zhu Yi Y   Wild Peter J PJ   Garnett Mathew J MJ   Bork Peer P   Beck Martin M   Liu Kexin K   Saez-Rodriguez Julio J   Elloumi Fathi F   Reinhold William C WC   Sander Chris C   Pommier Yves Y   Aebersold Ruedi R  

iScience 20191031

Here we describe a proteomic data resource for the NCI-60 cell lines generated by pressure cycling technology and SWATH mass spectrometry. We developed the DIA-expert software to curate and visualize the SWATH data, leading to reproducible detection of over 3,100 SwissProt proteotypic proteins and systematic quantification of pathway activities. Stoichiometric relationships of interacting proteins for DNA replication, repair, the chromatin remodeling NuRD complex, β-catenin, RNA metabolism, and  ...[more]

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