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Synaptosomal proteome from schizophrenia patients

ABSTRACT: Proteomic characterization of the synaptosome fraction of the orbitofrontal cortex using label-free and iTRAQ labeling strategies.

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Gilberto Domont

PROVIDER: MSV000086389 | MassIVE | Fri Oct 30 09:26:00 GMT 2020

SECONDARY ACCESSION(S): PXD006798

REPOSITORIES: MassIVE

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Publications

Synaptosomal Proteome of the Orbitofrontal Cortex from Schizophrenia Patients Using Quantitative Label-Free and iTRAQ-Based Shotgun Proteomics.

Velásquez Erika E Nogueira Fabio C S FCS Velásquez Ingrid I Schmitt Andrea A Falkai Peter P Domont Gilberto B GB Martins-de-Souza Daniel D

Journal of proteome research 20171013 12

Schizophrenia is a chronic and incurable neuropsychiatric disorder that affects about one percent of the world population. The proteomic characterization of the synaptosome fraction of the orbitofrontal cortex is useful for providing valuable information about the molecular mechanisms of synaptic functions in these patients. Quantitative analyses of synaptic proteins were made with eight paranoid schizophrenia patients and a pool of eight healthy controls free of mental diseases. Label-free and ...[more]

PMID: 28949146

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