Dataset Information

Schizophrenia and nicotine proteomics

ABSTRACT: Schizophrenia (SCHZ) and tobacco misuse comorbidity is frequently established during adolescence. However, comorbidity markers are still missing. Here, we used an label free quantitative proteomics approach to identify exclusively deregulated proteins in male and female mice modeled to SCHZ with a history of nicotine use during adolescence.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Tissue, Brain

DISEASE(S): Schizophrenia

SUBMITTER: Andres Rodriguez Vega

LAB HEAD: Andres Rodriguez Vega

PROVIDER: PXD043626 | Pride | 2023-10-24

REPOSITORIES: pride

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Dataset's files

Source:

			Action	DRS
	20211230_1_48_001.raw.zip	Raw
	20211230_1_48_002.raw.zip	Raw
	20211230_1_48_003.raw.zip	Raw
	CF_MeF_ALL_News_CTePCP.ProgenesisQIPExperiment	Other
	checksum.txt	Txt

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Publications

Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice.

Rodríguez-Vega Andrés A Dutra-Tavares Ana Carolina AC Souza Thainá P TP Semeão Keila A KA Filgueiras Claudio C CC Ribeiro-Carvalho Anderson A Manhães Alex C AC Abreu-Villaça Yael Y

International journal of molecular sciences 20230927 19

Tobacco misuse as a comorbidity of schizophrenia is frequently established during adolescence. However, comorbidity markers are still missing. Here, the method of label-free proteomics was used to identify deregulated proteins in the medial prefrontal cortex (prelimbic and infralimbic) of male and female mice modelled to schizophrenia with a history of nicotine exposure during adolescence. Phencyclidine (PCP), used to model schizophrenia (SCHZ), was combined with an established model of nicotine ...[more]

PMID: 37834084

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Project description:• Reference to published study making use of this data: • Cseke LJ, Tsai C-J, Rogers A, Nelsen MP, White HL, Karnosky DF, Podila GK. (2009) Transcriptomic comparison in the leaves of two aspen genotypes having similar carbon assimilation rates but different allocation patterns under elevated CO2. New Phytologist. submitted. • This study compared the leaf transcription profiles, physiological characteristics, and primary metabolites of two Populus tremuloides genotypes (clones 216 and 271) known to differ in their responses to long-term elevated [CO2] (e[CO2]) at the Aspen FACE site near Rhinelander, WI. • Physiological responses of these clones are similar in photosynthesis, stomatal conductance, and leaf area index under e[CO2] yet very different in growth enhancement (0-10% in clone 216; 40-50% in clone 271). While few genes responded to long-term exposure to e[CO2], the transcriptional activity of leaf e[CO2]-responsive genes was distinctly different between the clones, differentially impacting multiple pathways during both early and late growing seasons. • Analysis of transcript abundance and carbon/nitrogen biochemistry suggests that the CO2-responsive clone (271) partitions C into pathways associated with active defense/response to stress, carbohydrate/starch biosynthesis and subsequent growth. The CO2-unresponsive clone (216) partitions C into pathways associated with passive defense (e.g. lignin, phenylpropanoid) and cell wall thickening. • This study indicates that there is significant variation in expression patterns between different tree genotypes in response to long-term exposure to e[CO2]. Consequently, future efforts to improve productivity or other advantageous traits for carbon sequestration should include an examination of genetic variability in CO2 responsiveness. Keywords: Tree genotype comparison under elevated [CO2] 24 two-channel arrays, directly comparing RNA from trees grown in the ambient (control) [CO2] to RNA derived from the same genotype grown under e[CO2]. For each of 4 experimental conditions (clone 216 early season; clone 271 early season; clone 216 late season; clone 271 late season), three independent biological replicates derived from trees grown in three independent replicate FACE rings were used. In addition, each clone and time point included dye swap reciprocal two-color experiments for each biological replicate. Thus, six data points per cDNA are included (three biological replicates with two technical replicates each).