Dataset Information

Schizophrenia and nicotine proteomics

ABSTRACT: Schizophrenia (SCHZ) and tobacco misuse comorbidity is frequently established during adolescence. However, comorbidity markers are still missing. Here, we used an label free quantitative proteomics approach to identify exclusively deregulated proteins in male and female mice modeled to SCHZ with a history of nicotine use during adolescence.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Tissue, Brain

DISEASE(S): Schizophrenia

SUBMITTER: Andres Rodriguez Vega

LAB HEAD: Andres Rodriguez Vega

PROVIDER: PXD043626 | Pride | 2023-10-24

REPOSITORIES: pride

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Dataset's files

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			Action	DRS
	20211230_1_48_001.raw.zip	Raw
	20211230_1_48_002.raw.zip	Raw
	20211230_1_48_003.raw.zip	Raw
	CF_MeF_ALL_News_CTePCP.ProgenesisQIPExperiment	Other
	checksum.txt	Txt

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Publications

Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice.

Rodríguez-Vega Andrés A Dutra-Tavares Ana Carolina AC Souza Thainá P TP Semeão Keila A KA Filgueiras Claudio C CC Ribeiro-Carvalho Anderson A Manhães Alex C AC Abreu-Villaça Yael Y

International journal of molecular sciences 20230927 19

Tobacco misuse as a comorbidity of schizophrenia is frequently established during adolescence. However, comorbidity markers are still missing. Here, the method of label-free proteomics was used to identify deregulated proteins in the medial prefrontal cortex (prelimbic and infralimbic) of male and female mice modelled to schizophrenia with a history of nicotine exposure during adolescence. Phencyclidine (PCP), used to model schizophrenia (SCHZ), was combined with an established model of nicotine ...[more]

PMID: 37834084

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