Proteomics

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Case_PTMAinducesFilamentation_P124_Lumos

ABSTRACT: This dataset consists of 8 raw MS files, acquired on Orbitrap FusionLumosTribrid mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Nicolas Case and filtration was performed by Brett Larsen. Fractionation and mass spectrometry acquisition was performed by Cassandra Wong. Analysis was performed by Brett Larsen and Cassandra Wong. The files are associated with a manuscript submitted for publication by Nicola Case et al. The main goal of this paper was to functionally characterize the mechanism from macrophage-like cell lines that drive Candida albicans filamentation. This dataset identifies proteins present in fractions that drive C. albicans filamentation. Leah E. Cowen is the corresponding author of the manuscript (leah.cowen@utoronto.ca); Anne-Claude Gingras should be contacted for questions on this dataset (gingras@lunenfeld.ca). This submission is associated with 3 Supplementary Files README file File 1 README file Table 1 describes the composition of this dataset Table 2 lists all the peptide identification evidence (as per iProphet)

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Candida Albicans (ncbitaxon:5476) Mus Musculus (ncbitaxon:10090)

SUBMITTER: Anne-Claude Gingras  

PROVIDER: MSV000087531 | MassIVE | Thu May 27 12:01:00 BST 2021

REPOSITORIES: MassIVE

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Publications

The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans.

Case Nicola T NT   Duah Kwamaa K   Larsen Brett B   Wong Cassandra J CJ   Gingras Anne-Claude AC   O'Meara Teresa R TR   Robbins Nicole N   Veri Amanda O AO   Whitesell Luke L   Cowen Leah E LE  

Cell reports 20210801 8

Evasion of killing by immune cells is crucial for fungal survival in the host. For the human fungal pathogen Candida albicans, internalization by macrophages induces a transition from yeast to filaments that promotes macrophage death and fungal escape. Nutrient deprivation, alkaline pH, and oxidative stress have been implicated as triggers of intraphagosomal filamentation; however, the impact of other host-derived factors remained unknown. Here, we show that lysates prepared from macrophage-like  ...[more]

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