Proteomics

Dataset Information

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Sarikaya_HistoryMyopathy_P124_Lumos


ABSTRACT: This dataset consists of 3 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition mode. Cells and lysates were generated by Jonathan Volpatti. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Data analysis was performed by Cassandra Wong and Jonathan Volpatti. The files are associated with a manuscript submitted for publication by Ege Sarikaya et al. The paper performed a natural history study of Mtm1 KO mice to better understand XLMTM disease pathomechanisms. James J. Dowling is the corresponding author of the manuscript (james.dowling@sickkids.ca); Karen Colwill should be contacted for questions on this dataset (colwill@lunenfeld.ca) This submission is associated with 7 Supplementary File (in addition to this README file) Table 1 describes the composition of this dataset Table 2, 4, 6 describe all evidence for cytoplasm, membrane and nucleus fractions respectively Table 3, 5, 7 describe only peptide level analysis for cytoplasm, membrane and nucleus fractions respectively

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Karen Colwill  

PROVIDER: MSV000089841 | MassIVE | Thu Jul 07 09:56:00 BST 2022

SECONDARY ACCESSION(S): PXD035161

REPOSITORIES: MassIVE

Dataset's files

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Publications

Natural history of a mouse model of X-linked myotubular myopathy.

Sarikaya Ege E   Sabha Nesrin N   Volpatti Jonathan J   Pannia Emanuela E   Maani Nika N   Gonorazky Hernan D HD   Celik Alper A   Liang Yijng Y   Onofre-Oliveira Paula P   Dowling James J JJ  

Disease models & mechanisms 20220725 7


X-linked myotubular myopathy (XLMTM) is a severe monogenetic disorder of the skeletal muscle. It is caused by loss-of-expression/function mutations in the myotubularin (MTM1) gene. Much of what is known about the disease, as well as the treatment strategies, has been uncovered through experimentation in pre-clinical models, particularly the Mtm1 gene knockout mouse line (Mtm1 KO). Despite this understanding, and the identification of potential therapies, much remains to be understood about XLMTM  ...[more]

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