Dataset Information

DIA of Gasdermin-D knockout and cuprizone treated mouse brain tissue

ABSTRACT: Data-independent acquisition (DIA) of four replicates of mouse brain tissue lysate for each of the four conditions Gasdermin-D WT, Gasdermin-D KO, Gasdermin-D WT treated with cuprizone, and Gasdermin-D KO treated with cuprizone.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Olivier Julien

PROVIDER: MSV000091185 | MassIVE | Thu Feb 02 10:54:00 GMT 2023

REPOSITORIES: MassIVE

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Publications

Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis.

Pollock Niall M NM Fernandes Jason P JP Woodfield Jenilee J Moussa Eman E Hlavay Brittyne B Branton William G WG Wuest Melinda M Mohammadzadeh Nazanin N Schmitt Laura L Plemel Jason R JR Julien Olivier O Wuest Frank F Power Christopher C

Brain, behavior, and immunity 20231031

Neuroinflammation coupled with demyelination and neuro-axonal damage in the central nervous system (CNS) contribute to disease advancement in progressive multiple sclerosis (P-MS). Inflammasome activation accompanied by proteolytic cleavage of gasdermin D (GSDMD) results in cellular hyperactivation and lytic death. Using multiple experimental platforms, we investigated the actions of GSDMD within the CNS and its contributions to P-MS. Brain tissues from persons with P-MS showed significantly inc ...[more]

PMID: 37914099

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