Transmission
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB28216 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Although composition and functional potential of the human gut microbiota evolve over lifespan, kinship has been identified as a key covariate of microbial community diversification. To date, sharing of microbiota features within families has however mostly been assessed between parents and their direct offspring. Here, we investigate potential transmission and persistence of familial microbiome patterns and microbial genotypes in a family cohort (N=102) spanning three to five generations over the same female bloodline. We observe microbiome community composition to be associated with kinship, with seven (low-abundant) genera displaying familial distribution patterns. While kinship and current cohabitation emerged as closely entangled variables, our explorative analyses of microbial genotype distribution and transmission estimates point at the latter as a key covariate of strain dissemination. Highest potential transmission rates are estimated between sisters and mother-daughter pairs, decreasing with increasing daughter’s age, and being higher among cohabiting pairs than those living apart. Although rare, we do detect potential transmission events spanning three and four generations, primarily involving species of the genera Alistipes and Bacteroides. Overall, while our analyses confirm the existence of family-bound microbiome community profiles, transmission or co-acquisition of bacterial strains appears to be strongly linked to cohabitation.
| EGAS00001005649 | EGA
Project description:Although composition and functional potential of the human gut microbiota evolve over lifespan, kinship has been identified as a key covariate of microbial community diversification. To date, sharing of microbiota features within families has however mostly been assessed between parents and their direct offspring. Here, we investigate potential transmission and persistence of familial microbiome patterns and microbial genotypes in a family cohort (N=102) spanning three to five generations over the same female bloodline. We observe microbiome community composition to be associated with kinship, with seven (low-abundant) genera displaying familial distribution patterns. While kinship and current cohabitation emerged as closely entangled variables, our explorative analyses of microbial genotype distribution and transmission estimates point at the latter as a key covariate of strain dissemination. Highest potential transmission rates are estimated between sisters and mother-daughter pairs, decreasing with increasing daughter’s age, and being higher among cohabiting pairs than those living apart. Although rare, we do detect potential transmission events spanning three and four generations, primarily involving species of the genera Alistipes and Bacteroides. Overall, while our analyses confirm the existence of family-bound microbiome community profiles, transmission or co-acquisition of bacterial strains appears to be strongly linked to cohabitation.
| EGAS00001005651 | EGA
Project description:The person-to-person transmission landscape of the gut and oral microbiomes
| PRJEB45799 | ENA
Project description:Streptococcus pyogenes transmission study
| PRJEB2104 | ENA
Project description:The goal of OOCYSTOP is based on an innovative concept to block malaria transmission by development of new drugs that will be delivered (1) to oocysts in infected mosquitoes and (2) to early stages in human infection by the sporozoite
2023-02-28 | MSV000091377 | MassIVE
Project description:This SuperSeries is composed of the following subset Series: GSE21311: Maternal influences on the transmission of leukocyte gene expression profiles in population samples (Red Cross Donors) GSE21342: Maternal influences on the transmission of leukocyte gene expression profiles in population samples (mother and child) Refer to individual Series
2011-01-01 | E-GEOD-21345 | biostudies-arrayexpress
Project description:Variation and transmission of the human gut microbiota across generations - shotgun sequencing data
| EGAD00001008207 | EGA
Project description:Variation and transmission of the human gut microbiota across generations - 16S sequencing data
| EGAD00001008195 | EGA
Project description:Two independent ES cell lines (D4 and C2) were assessed for chimerism and germline transmission. Although these lines were able to produce chimerism at early passage, no germ line transmission was seen. After passaging in a proprietary medium and subcloning by detaching loosely connected cells and culturing in the recommended medium, both lines experienced an increase in potential as evidenced by an enhanced ability to go germ line. Analysis of early passage, and late passage detached and attached cells will allow the determination of genes that may be implicated in the increase of potential seen in these cells. Note: additional replicates may be added at a later date. Keywords: embryonic stem cells, chimerism, germline transmission
2006-01-24 | GSE4087 | GEO
Project description:Transmission of Mycobacterium Tuberculosis in Switzerland over 25 Years
| PRJEB5925 | ENA