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Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis

ABSTRACT: Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis

PROVIDER: PRJEB4606 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR341301_1.fastq.gz	Fastqsanger.gz
	ERR341301_2.fastq.gz	Fastqsanger.gz
	ERR341302_1.fastq.gz	Fastqsanger.gz
	ERR341302_2.fastq.gz	Fastqsanger.gz

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Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.

Project description:Vulvovaginal candidiasis (VVC) is one of the most prevalent vaginal infectious diseases, and there are controversial reports regarding the diversity of the associated vaginal microbiota. We determined the vaginal microbial community in patients with VVC, bacterial vaginosis (BV), and mixed infection of VVC and BV using Illumina sequencing of 16S rRNA tags. Our results revealed for the first time the highly variable patterns of the vaginal microbiome from VVC patients. In general, the alpha-diversity results of species richness and evenness showed the following order: normal control < VVC only < mixed BV and VVC infection < BV only. The beta-diversity comparison of community structures also showed an intermediate composition of VVC between the control and BV samples. A detailed comparison showed that, although the control and BV communities had typical patterns, the vaginal microbiota of VVC is complex. The mixed BV and VVC infection group showed a unique pattern, with a relatively higher abundance of Lactobacillus than the BV group and higher abundance of Prevotella, Gardnerella, and Atopobium than the normal control. In contrast, the VVC-only group could not be described by any single profile, ranging from a community structure similar to the normal control (predominated with Lactobacillus) to BV-like community structures (abundant with Gardnerella and Atopobium). Treatment of VVC resulted in inconsistent changes of the vaginal microbiota, with four BV/VVC samples recovering to a higher Lactobacillus level, whereas many VVC-only patients did not. These results will be useful for future studies on the role of vaginal microbiota in VVC and related infectious diseases.

| S-EPMC3827160 | biostudies-literature

Transcriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome

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Transcriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome

Project description:RNA-seq analysis of an in vivo murine model of vulvovaginal candidiasis Murine vaginas were infected with Candida albicans and harvested for RNA-seq analysis 3 days post-infection

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Project description:The vaginal microbiome in reproductive age women

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Vaginal epithelial gene expression in postmenopausal women suffering from vaginal dryness

Project description:The onset of menopause is accompanied by a dramatic increase in reported symptoms of vaginal dryness, soreness, irritation or itching, pain with intercourse and bleeding after intercourse. Collectively these affect 25-50% of women of post-menopausal age and significantly impact their quality of life. To examine how gene expression differs between these groups, surface vaginal epithelial cells were collected from postmenopausal women suffering from vaginal dryness and appropriate controls not suffering from dryness. Affymetrix GeneChip Human 1.0 ST microarrays were performed on RNA isolated from ten participants.

2011-11-12 | GSE26761 | GEO

Vaginal epithelial gene expression in postmenopausal women suffering from vaginal dryness

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Global Expression of Molecular Transporters in the Human Vaginal Tract

Project description:Pre-exposure chemoprophylaxis using antiretroviral agents is a promising strategy for the prevention of sexual HIV transmission in women. Molecular transporters in the human vaginal tract may play a pivotal role in determining drug disposition and, consequently, pharmacodynamic outcomes in these efforts. Little is known, however, on the expression of these transporters in vaginal tissues, representing a critical knowledge gap. Our study analyzed the genome-wide transcriptome in 44 vaginal tissue samples from 6 reproductive-age women undergoing gynecologic surgeries. The genome-wide transcriptome in 44 vaginal tissue samples from 6 reproductive-age women (20-56 years old) undergoing gynecologic surgeries was measured.

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Project description:Diversity of vaginal microbiome during recurrent vulvovaginal candidiasis

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Project description:Formulations with herbal medicines (HM) may emerge as alternatives for topical treatment of vaginal candidiasis when the resistance to antifungal drugs has increased in Candida species. We developed a vaginal formulation with HM (S. adstringens shell extract characterized by molecular networking, and M. alternifolia Chell essential oil, 46% of terpinen-4-ol).

2020-05-27 | MSV000085475 | GNPS

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