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Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages

ABSTRACT: Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages

PROVIDER: PRJNA428374 | ENA |

REPOSITORIES: ENA

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Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages

Project description:Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages

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Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages [in vivo]

Project description:Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages [in vivo]

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Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages [in vitro]

Project description:Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages [in vitro]

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Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-29 | GSE125029 | GEO

Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages

Project description:RNAseq were performed to analyze the transcriptomic differences between healthy homeostatic MSC, pre-leukemic MSC and recovered MSC.

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Mesenchymal stromal cells orchestrate the overhaul of leukemia bone marrow microenvironment via educating macrophages [in vivo]

Project description:RNAseq were performed to analyze the transcriptomic differences between macrophage and MSC-educated macrophages in vivo.

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Bone marrow microenvironment: interaction of monocytes and stromal cells

Project description:Two human stromal cell lines, HS-5 and HS-27a, represent functionally distinct components of the bone marrow microenvironment. A third influential component of the microenvironment is resident monocytes and macrophages. The baseline expression profile of normal peripheral blood monocytes was determined and their effect on the gene expression of the stromal cells was investigated in a co-culture sytem. Control RNA for all samples was Stratagene Universal human reference RNA. Keywords: Cell Line Comparison and Culture Comparison

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Dual-species microarray for assessing gene expression in stromal microenvironment, cancer cells and their interactions

Project description:This SuperSeries is composed of the following subset Series: GSE23054: Dual-species microarray for assessing gene expression in stromal microenvironment, cancer cells and their interactions (v1 array) GSE23364: Dual-species microarray for assessing gene expression in stromal microenvironment, cancer cells and their interactions (v2 array) Refer to individual Series

2010-08-04 | E-GEOD-23377 | biostudies-arrayexpress

Transcription profiling by array of human bone marrow stromal cells lines cultured with monocytes to investigate interactions in the hematopoietic microenvironment

Project description:The hematopoietic microenvironment consists of non-hematopoietic derived stromal elements and hematopoietic derived monocytes and macrophages which interact and function together to control the proliferation and differentiation of early blood-forming cells. Two human stromal cell lines (HS-5 and HS-27a) representing distinct functional components of this microenvironment have been extensively characterized and shown to influence monocyte gene expression. This series of gene expression profiles is intended to extend the previous studies and identify which gene expression changes may require cell-cell contact or occur in the stromal cells as a result of monocyte influence;or in the monocytes as a result of stormal influences. Experiment Overall Design: Two human bone marrow stromal cell lines (HS5 and HS27a) were cultured with and without monocytes (CD14+ cells) from 2 different donors. Experiment Overall Design: culture condition: stroma no monocytes: HS5-1, HS5-2, HS27a-1, HS27a-2 Experiment Overall Design: culture condition: stroma with monocytes: HS5-MO-1, HS5-MO-2, HS27a-MO-1, HS27a-MO-2 Experiment Overall Design: donor: donor 3: HS5-MO-1, HS27a-MO-1 Experiment Overall Design: donor: donor 4: HS5-MO-2, HS27a-MO-2 Experiment Overall Design: cell line: HS5: HS5-1, HS5-2, HS5-MO-1, HS5-MO-2 Experiment Overall Design: cell line: HS27a: HS27a-1, HS27a-2, HS27a-MO-1, HS27a-MO-2

2008-04-07 | E-GEOD-10595 | biostudies-arrayexpress

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