Project description:Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of Papillary Thyroid Cancer tissue sample and adjacent normal tissue. The goals of this study are to analysis the different circRNAs expression between Cancer tissue sample and adjacent normal tissue. Quantitative reverse transcription polymerase chain reaction (qRT–PCR) methods and to evaluate protocols for optimal high-throughput data analysis. We performed circRNA-seq in Papillary Thyroid Cancer tissue sample and adjacent normal tissue. We found that through the deep sequencing of four pairs PTC and adjacent nontumor tissues, we identified 16569 circRNAs, 720 circRNAs were differentials expressed, among them, 301 upregulated and 419 downregulated.

2021-03-29 | GSE171011 | GEO

miRNA expresion data from PDAC Tumour, adjacent normal and PDX tissue samples

Project description:mRNA expression profiling of pancreatic cancer, comparing adjacent normal tissue, patient tumour and first generation patient derived xenograft tumours Fresh tumour samples for human pancreatic adenocarcinoma patients were implanted in SCID mice. 70% of these pancreatic ductal adenocarcinoma patients grew as PDX tumours, confirmed by histopathology. Frozen samples from F1 PDX tumours could be later successful passaged in SCID mice to F2 PDX tumours. The human origin of the PDX was confirmed using human specific antibodies; however, the stromal component was replaced by murine cells. Cell lines were successfully developed from three PDX tumours. RNA was extracted from 8 PDX tumours and where possible, corresponding primary tumour and adjacent normal tissues. mRNA profiles of tumour vs F1 PDX and normal vs tumour were compared by Affymetric microarray analysis

2023-03-06 | GSE207345 | GEO

microRNA profiling by array of paired samples tumor tissue/normal adjacent tissue from colon cancer patients

Project description:Ten arrays were performed on the RNA extracts from 10 patients' samples, each of them contained the paired samples tumor tissue/ normal adjacent tissue.

2018-01-17 | E-MTAB-5443 | biostudies-arrayexpress

Keloid tissue: active keloid lesion vs. adjacent normal skin tissue

Project description:Transcriptional profiling of active keloid lesion and adjacent control normal skin tissue from human. Each control and lesion sample was derived from a matched individual.

2017-07-01 | GSE90051 | GEO

Genome wide DNA methylation of Psoriasis patients from disease and adjacent Normal skin skin tissue samples

Project description:Genome wide DNA methylation profiling of psoriatic disease skin tissue and adjacent Normal skin samples. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 450,000 CpGs in tissue samples. Total 48 samples were taken including 24 paired tissues.

2018-10-29 | GSE115797 | GEO

Expression data from human glioma tissues and corresponding adjacent non-tumor tissues

Project description:We performed microarray expression profiling to analyze the differentially expressed genes between 19 human glioma tissues and corresponding adjacent non-tumor tissues.

2022-01-26 | GSE188256 | GEO

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