Organ-differential Regulation of Vascular Development by DEAD-box Helicase 24
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA768417 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR16190667_1.fastq.gz | Fastqsanger.gz | |||
| SRR16190667_2.fastq.gz | Fastqsanger.gz | |||
| SRR16190668_1.fastq.gz | Fastqsanger.gz | |||
| SRR16190668_2.fastq.gz | Fastqsanger.gz | |||
| SRR16190669_1.fastq.gz | Fastqsanger.gz |
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Project description:How cells regulate gene expression in a precise spatiotemporal manner during organismal development is a fundamental question in biology. Although the role of transcriptional condensates in gene regulation has been established, little is known about the function and regulation of these molecular assemblies in the context of animal development and physiology. Here we show that the evolutionarily conserved DEAD-box helicase DDX-23 controls cell fate in Caenorhabditis elegans by binding to and facilitating the condensation of MAB-10, the Caenorhabditis elegans homolog of mammalian NGFI-A-binding (NAB) protein. MAB-10 is a transcriptional cofactor that functions with the early growth response (EGR) protein LIN-29 to regulate the transcription of genes required for exiting the cell cycle, terminal differentiation, and the larval-to-adult transition. We suggest that DEAD-box helicase proteins function more generally during animal development to control the condensation of NAB proteins important in cell identity and that this mechanism is evolutionarily conserved. In mammals, such a mechanism might underlie terminal cell differentiation and when misregulated might promote cancerous growth.
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