Dataset Information

ZNF322A_lung cancer_iTRAQ_LC-MSMS

ABSTRACT: ZNF322A, a transcription factor, has been identified as a novel putative oncogene in lung cancer. There are over 50% of amplification rates in both Asia and Caucasian lung cancer patients. This study is to use proteomics approach to establish the protein interaction network of ZNF322A.

INSTRUMENT(S): Synapt G2 HDMS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Lung Adenocarcinoma

SUBMITTER: Li-Ling Lin

LAB HEAD: Hsueh-Fen Juan

PROVIDER: PXD001123 | Pride | 2016-07-07

REPOSITORIES: Pride

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Publications

Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.

Jen J J Lin L-L LL Chen H-T HT Liao S-Y SY Lo F-Y FY Tang Y-A YA Su W-C WC Salgia R R Hsu C-L CL Huang H-C HC Juan H-F HF Wang Y-C YC

Oncogene 20150817 18

ZNF322A encoding a classical Cys2His2 zinc finger transcription factor was previously revealed as a potential oncogene in lung cancer patients. However, the oncogenic role of ZNF322A and its underlying mechanism in lung tumorigenesis remain elusive. Here we show ZNF322A protein overexpression in 123 Asian and 74 Caucasian lung cancer patients. Multivariate Cox regression analysis indicated that ZNF322A was an independent risk factor for a poor outcome in lung cancer, corroborating the Kaplan-Mei ...[more]

PMID: 26279304

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	SiRNA_20-1.raw.zip	Raw
	SiRNA_20-2.mgf	Mgf
	SiRNA_20-2.raw.zip	Raw
	SiRNA_21-1.mgf	Mgf