Dataset Information

Mouse cardiomyocytes LC/MS/MS - Membrane Proteomics of Impaired Energetics and Cytoskeletal Disorganization in Elderly Diet-Induced Diabetic Mice

ABSTRACT: Differential Membrane Proteomics Profiles of isolated cardio myocytes in HFD mice

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Cardiocyte

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Feng-wen Jiang

LAB HEAD: Chia-Li Han

PROVIDER: PXD002881 | Pride | 2017-08-28

REPOSITORIES: Pride

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			Action	DRS
	P_WAS_20150520_ALL.xml	Xml
	Was_GUG_F1_20150428_01.raw	Raw
	Was_GUG_F1_20150428_02.raw	Raw
	Was_GUG_F2_20150428_01.raw	Raw
	Was_GUG_F2_20150428_02.raw	Raw

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Publications

Membrane Proteomics of Impaired Energetics and Cytoskeletal Disorganization in Elderly Diet-Induced Diabetic Mice.

Hung Chung-Lieh CL Pan Szu-Hua SH Han Chia-Li CL Chang Ching-Wei CW Hsu Yuan-Ling YL Su Cheng-Huang CH Shih Shou-Chuan SC Lai Yu-Jun YJ Chiang Chiau Jen-Shiu JS Yeh Hung-I HI Liu Chia-Yuan CY Lee Hung-Chang HC Lam Carolyn S P CSP

Journal of proteome research 20170913 10

Diabetic cardiomyopathy is a well-recognized complication of diabetes, but its pathophysiology is unclear. We aimed to investigate the mechanisms underlying cardiac dysfunction in an elderly type 2 diabetic (T2DM) mouse model, using membrane proteomic analyses. Elderly mice were fed a high fat diet for 12 weeks to induce T2DM, and myocardial structure and function were assessed by echocardiography. Cardiomyocytes were isolated by Langendorff perfusion and subjected to iTRAQ-based quantitative me ...[more]

PMID: 28823169

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