Dataset Information

Accessibilome of Human Glioblastoma

ABSTRACT: Functional targeted therapy has unfortunately failed to improve the outcome of glioblastoma patients. Success stories evidenced by the use of antibody-drug conjugates in other tumor types are encouraging, but targets specific to glioblastoma and accessible through the blood stream remain scarce. In the current work we have identified and characterized novel and accessible proteins using an innovative proteomic approach on 6 human glioblastomas. We have also analysed U87 tumors grown of chicken chorioallantoic membrane (CAM) and normal brains from mice as controls. Both were processed in the same fashion as the human tumors.

REANALYSED by: PAe005158

INSTRUMENT(S): Bruker Daltonics esquire series

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Glial Cell, Brain

DISEASE(S): Brain Glioblastoma Multiforme

SUBMITTER: Andrei Turtoi

LAB HEAD: Vincent Castronovo

PROVIDER: PXD001398 | Pride | 2014-10-17

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	MASCOT-RESULTS.zip	Other
	MGF.zip	Other
	YEP.zip	Other

Items per page:

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Publications

Accessibilome of human glioblastoma: collagen-VI-alpha-1 is a new target and a marker of poor outcome.

Turtoi Andrei A Blomme Arnaud A Bianchi Elettra E Maris Pamela P Vannozzi Riccardo R Naccarato Antonio Giuseppe AG Delvenne Philippe P De Pauw Edwin E Bevilacqua Generoso G Castronovo Vincent V

Journal of proteome research 20141103 12

Functional targeted therapy has unfortunately failed to improve the outcome of glioblastoma patients. Success stories evidenced by the use of antibody-drug conjugates in other tumor types are encouraging, but targets specific to glioblastoma and accessible through the bloodstream remain scarce. In the current work, we have identified and characterized novel and accessible proteins using an innovative proteomic approach on six human glioblastomas; the corresponding data have been deposited in the ...[more]

PMID: 25325876

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