Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Macaca Mulatta (rhesus Macaque)
TISSUE(S): Heart
DISEASE(S): Cardiovascular System Disease
SUBMITTER: Vidya Venkatraman
LAB HEAD: Dr. Jennifer Van Eyk
PROVIDER: PXD001842 | Pride | 2018-10-19
REPOSITORIES: Pride
Action | DRS | |||
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36L8mU4p-H300D.mgf | Mgf | |||
36L8mU4p-H300D.mzXML | Mzxml | |||
36L8mU4p-H304D.mgf | Mgf | |||
36L8mU4p-H304D.mzXML | Mzxml | |||
36L8mU4p-HNJ01.mgf | Mgf |
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Science translational medicine 20150601 292
The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging heart remains elusive. We present the cardiac proteomes of young and old rhesus monkeys and rats, from which we show that certain age-associated remodeling events within the cardiomyocyte cytoskeleton are highly conserved and beneficial rather than del ...[more]