Dataset Information

The extracellular vesicles of the helminth pathogen, Fasciola hepatica: biogenesis pathways and cargo molecules involved in parasite pathogenesis

ABSTRACT: We reveal that whilst the molecular “machinery” required for EV biogenesis is constitutively expressed across the intra-mammalian development stages of the parasite, the cargo molecules packaged within the EVs are regulated, most likely to facilitate the parasites migration through host tissue and to counteract host immune attack.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Fasciola Hepatica (liver Fluke)

TISSUE(S): Epithelial Cell

SUBMITTER: Luz Valero

LAB HEAD: Antonio Marcilla

PROVIDER: PXD002570 | Pride | 2015-10-14

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	A1_outermost.mgf.mgf	Mgf
	A1_outermost.mgf.pride.mgf.gz	Mgf
	A1_outermost.mzid.gz	Mzid
	AM_130424.C1_MGFPeaklist.mgf	Mgf
	AM_130424.C1_MGFPeaklist.pride.mgf.gz	Mgf

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Publications

The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis.

Cwiklinski Krystyna K de la Torre-Escudero Eduardo E Trelis Maria M Bernal Dolores D Dufresne Philippe J PJ Brennan Gerard P GP O'Neill Sandra S Tort Jose J Paterson Steve S Marcilla Antonio A Dalton John P JP Robinson Mark W MW

Molecular & cellular proteomics : MCP 20151020 12

Extracellular vesicles (EVs) released by parasites have important roles in establishing and maintaining infection. Analysis of the soluble and vesicular secretions of adult Fasciola hepatica has established a definitive characterization of the total secretome of this zoonotic parasite. Fasciola secretes at least two subpopulations of EVs that differ according to size, cargo molecules and site of release from the parasite. The larger EVs are released from the specialized cells that line the paras ...[more]

PMID: 26486420

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