Dataset Information
Identification of Fic substrates in bacteria
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Pseudomonas Fluorescens Escherichia Coli
TISSUE(S): Prokaryotic Cell
SUBMITTER: 
Ernesto Nakayasu
LAB HEAD: Ernesto S. Nakayasu
PROVIDER: PXD003077 | Pride | 2016-02-01
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 030515_Ernesto_Luo_gyrB_1_A.wiff | Wiff | |||
| 030515_Ernesto_Luo_gyrB_1_A.wiff.scan | Wiff | |||
| 030515_Ernesto_Luo_gyrBstar_1_A.wiff | Wiff | |||
| 030515_Ernesto_Luo_gyrBstar_1_A.wiff.scan | Wiff | |||
| msms.txt | Txt |
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Publications
Identification of Fic-1 as an enzyme that inhibits bacterial DNA replication by AMPylating GyrB, promoting filament formation.
Science signaling 20160126 412
The morphology of bacterial cells is important for virulence, evasion of the host immune system, and coping with environmental stresses. The widely distributed Fic proteins (filamentation induced by cAMP) are annotated as proteins involved in cell division because of the presence of the HPFx[D/E]GN[G/K]R motif. We showed that the presence of Fic-1 from Pseudomonas fluorescens significantly reduced the yield of plasmid DNA when expressed in Escherichia coli or P. fluorescens. Fic-1 interacted wit ...[more]