Dataset Information
Podocyte Focal Adhesion Proteome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Podocyte (sensu Diptera), Kidney
SUBMITTER: 
Joern Dengjel
LAB HEAD: Jörn Dengjel
PROVIDER: PXD010626 | Pride | 2018-12-14
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20151230_VD_CFP_912_1.raw | Raw | |||
| 20151230_VD_CFP_912_10.raw | Raw | |||
| 20151230_VD_CFP_912_2.raw | Raw | |||
| 20151230_VD_CFP_912_3.raw | Raw | |||
| 20151230_VD_CFP_912_4.raw | Raw |
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Publications
ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier.
Developmental cell 20181129 6
Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration barrier and withstand high mechanical forces through a complex network of cellular protrusions. Here, we show that Arp2/3-dependent actin polymerization controls actomyosin contractility and focal adhesion maturation of podocyte protrusions and thereby regulates formation, maintenance, and capacity to adapt to mechanical requirements of the filtration barrier. We find that N-WASP-Arp2/3 define the devel ...[more]
