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NHE9 interactome(HEK293) - Effect of disease-associated SLC9A9 mutations on protein-protein interaction networks: implications for molecular mechanisms for ADHD and autism

ABSTRACT: To characterize the interactome of NHE9 and quantify changes due to ADHD or autism-related mutations.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Early Embryonic Cell, Kidney

DISEASE(S): Attention Deficit Hyperactivity Disorder,Autism Spectrum Disorder

SUBMITTER: Yanli Zhang-James

LAB HEAD: Yanli James

PROVIDER: PXD003310 | Pride | 2019-09-10

REPOSITORIES: Pride

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			Action	DRS
	JH_1.msf	Msf
	JH_1.raw	Raw
	JH_2.msf	Msf
	JH_2.raw	Raw
	JH_3.msf	Msf

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Publications

Effect of disease-associated SLC9A9 mutations on protein-protein interaction networks: implications for molecular mechanisms for ADHD and autism.

Zhang-James Yanli Y Vaudel Marc M Mjaavatten Olav O Berven Frode S FS Haavik Jan J Faraone Stephen V SV

Attention deficit and hyperactivity disorders 20190329 1

Na<sup>+</sup>/H<sup>+</sup> Exchanger 9 (NHE9) is an endosomal membrane protein encoded by the Solute Carrier 9A, member 9 gene (SLC9A9). SLC9A9 has been implicated in attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), epilepsy, multiple sclerosis and cancers. To better understand the function of NHE9 and the effects of disease-associated variants on protein-protein interactions, we conducted a quantitative analysis of the NHE9 interactome using co-immunoprecipit ...[more]

PMID: 30927234

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