Dataset Information

Quantitative Profiling of Protein S-Glutathionylation during Nanoparticle-Induced Oxidative Stress

ABSTRACT: Quantitative profiling of protein s-glutathionylation (SSG) reveals redox-dependent regulation of macrophage function during nanoparticle-induced oxidative stress

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Macrophage Cell Line

SUBMITTER: Matthew Monroe

LAB HEAD: Weijun Qian

PROVIDER: PXD003356 | Pride | 2016-08-02

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	SSG_Raw_CoO_TMT6_17JUL14_Frodo_14-01-35.mgf	Mgf
	SSG_Raw_CoO_TMT6_17JUL14_Frodo_14-01-35.pride.mgf.gz	Mgf
	SSG_Raw_CoO_TMT6_17JUL14_Frodo_14-01-35.raw	Raw
	SSG_Raw_CoO_TMT6_17JUL14_Frodo_14-01-35_msgfplus.mzid.gz	Mzid
	SSG_Raw_CoO_TMT6_17JUL14_Frodo_14-01-35_msgfplus.pride.mztab.gz	Mztab

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Publications

Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function during Nanoparticle-Induced Oxidative Stress.

Duan Jicheng J Kodali Vamsi K VK Gaffrey Matthew J MJ Guo Jia J Chu Rosalie K RK Camp David G DG Smith Richard D RD Thrall Brian D BD Qian Wei-Jun WJ

ACS nano 20151229 1

Engineered nanoparticles (ENPs) are increasingly utilized for commercial and medical applications; thus, understanding their potential adverse effects is an important societal issue. Herein, we investigated protein S-glutathionylation (SSG) as an underlying regulatory mechanism by which ENPs may alter macrophage innate immune functions, using a quantitative redox proteomics approach for site-specific measurement of SSG modifications. Three high-volume production ENPs (SiO2, Fe3O4, and CoO) were ...[more]

PMID: 26700264

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