Proteomics

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Human AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 2


ABSTRACT: Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while regaining high levels at relapse. This suggested a dynamic regulation of apoptosis. This data is from the lysate fraction of the secretomes described in PXD001476.

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bone Marrow, Bone Marrow Cell

DISEASE(S): Acute Leukemia

SUBMITTER: Sander Piersma  

LAB HEAD: Connie Ramona Jimenez

PROVIDER: PXD003471 | Pride | 2016-02-03

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
090603_03.RAW Raw
090603_07.RAW Raw
090603_08.RAW Raw
090603_10.RAW Raw
090603_11.RAW Raw
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Publications

Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.

Wojtuszkiewicz Anna A   Schuurhuis Gerrit J GJ   Kessler Floortje L FL   Piersma Sander R SR   Knol Jaco C JC   Pham Thang V TV   Jansen Gerrit G   Musters RenĂ© J P RJ   van Meerloo Johan J   Assaraf Yehuda G YG   Kaspers Gertjan J L GJ   Zweegman Sonja S   Cloos Jacqueline J   Jimenez Connie R CR  

Molecular & cellular proteomics : MCP 20160122 4


Expression of apoptosis-regulating proteins (B-cell CLL/lymphoma 2 - BCL-2, Myeloid Cell Leukemia 1 - MCL-1, BCL-2 like 1 - BCL-X and BCL-2-associated X protein - BAX) in acute myeloid leukemia (AML) blasts at diagnosis is associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while regaining high levels at relapse. Herein, we further explored this aspect of dynamic apoptosis regulation in AML. First, we showe  ...[more]

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