Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Candida Albicans (yeast)
SUBMITTER: Jonathan Krieger
LAB HEAD: Leah E. Cowen
PROVIDER: PXD003916 | Pride | 2016-12-05
REPOSITORIES: Pride
Items per page: 1 - 5 of 30 |
G3 (Bethesda, Md.) 20170105 1
Disruption of protein quality control can be detrimental, having toxic effects on single cell organisms and contributing to neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's in humans. Here, we examined the effects of polyglutamine (polyQ) aggregation in a major fungal pathogen of humans, Candida albicans, with the goal of identifying new approaches to disable this fungus. However, we discovered that expression of polyQ stretches up to 230Q had no effect on C. albicans ...[more]