Dataset Information

Utx interactome in mouse myeloid progenitor cells

ABSTRACT: Immunoprecipitation of Utx followed by mass spectrometry analysis to identify Utx binding partners in mouse myeloid progenitor cells.

OTHER RELATED OMICS DATASETS IN: GSE86490PRJNA393986PRJNA342026

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Common Myeloid Progenitor

DISEASE(S): Leukemia

SUBMITTER: Hendrik Weisser

LAB HEAD: Jyoti Sharma Choudhary

PROVIDER: PXD005011 | Pride | 2018-04-30

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	GG01_C1allbands_Percolator.msf	Msf
	GG01_C2allbands_Percolator.msf	Msf
	GG01_C3allbands_Percolator.msf	Msf
	GG01_UG1allbands_Percolator.msf	Msf
	GG01_UG3allbands_Percolator.msf	Msf

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Publications

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.

Gozdecka Malgorzata M Meduri Eshwar E Mazan Milena M Tzelepis Konstantinos K Dudek Monika M Knights Andrew J AJ Pardo Mercedes M Yu Lu L Choudhary Jyoti S JS Metzakopian Emmanouil E Iyer Vivek V Yun Haiyang H Park Naomi N Varela Ignacio I Bautista Ruben R Collord Grace G Dovey Oliver O Garyfallos Dimitrios A DA De Braekeleer Etienne E Kondo Saki S Cooper Jonathan J Göttgens Berthold B Bullinger Lars L Northcott Paul A PA Adams David D Vassiliou George S GS Huntly Brian J P BJP

Nature genetics 20180507 6

The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through noncatalytic functions, a property shared with its catalytically inactive Y-chromosome paralog, UTY (or KDM6C). In keeping with this, we demonstrate concomitant loss/mutation of KDM6A (UTX) and UTY in multiple human cancers. Mechanistically, global genomic profiling showed only minor changes in H3K27me3 but ...[more]

PMID: 29736013

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