Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Embryo, Embryonic Stem Cell
SUBMITTER: Mike Tatham
LAB HEAD: Ronald T Hay
PROVIDER: PXD013737 | Pride | 2019-06-17
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
20170929_MT_Celine_90m_01.raw | Raw | |||
20170929_MT_Celine_90m_02.raw | Raw | |||
20170929_MT_Celine_90m_03.raw | Raw | |||
20170929_MT_Celine_90m_04.raw | Raw | |||
20170929_MT_Celine_90m_05.raw | Raw |
Items per page: 5 1 - 5 of 101 |
Wang Yu Y Tatham Michael H MH Schmidt-Heck Wolfgang W Swann Carolyn C Singh-Dolt Karamjit K Meseguer-Ripolles Jose J Lucendo-Villarin Baltasar B Kunath Tilo T Rudd Timothy R TR Smith Andrew J H AJH Hengstler Jan G JG Godoy Patricio P Hay Ronald T RT Hay David C DC
iScience 20190524
During mammalian development, liver differentiation is driven by signals that converge on multiple transcription factor networks. The hepatocyte nuclear factor signaling network is known to be essential for hepatocyte specification and maintenance. In this study, we have generated deletion and point mutants of hepatocyte nuclear factor-4alpha (HNF4α) to precisely evaluate the function of protein domains during hepatocyte specification from human pluripotent stem cells. We demonstrate that nuclea ...[more]