Proteomics

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Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-virus interference phenomenon

ABSTRACT: Cellular models have provided significant advances on molecular bases of bipartite interactions between either an arbovirus or a bacterial symbiont with a given arthropod vector. However, although an interference phenomenon was evidenced in tripartite interaction arbovirus-symbiont-mosquito vector very little is known regarding the mechanisms involved. Using large-scale proteome profiling, we characterized proteins differentially expressed in Aedes albopictus cells infected by the symbiotic bacterium Wolbachia and the Chikungunya virus (CHIKV). These proteins were mostly related to cellular processes involved in glycolysis process, protein metabolism, translation and amino acid metabolism. The presence of Wolbachia impacted significantly the protein profiles, including sequestration of proteins such as structural polyprotein and capsid viral proteins that may affect replication and assembly of CHIKV in cellulo. This study provides insights into the molecular pathways involved in the tripartite interaction mosquito-Wolbachia-virus and may help in defining targets for the better implementation of Wolbachia-based strategy for disease transmission control.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Aedes <genus>

TISSUE(S): Cell Culture

SUBMITTER: Dupuy Jean-William  

LAB HEAD: Patrick Mavingui

PROVIDER: PXD005091 | Pride | 2018-03-14

REPOSITORIES: Pride

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UP_2015_04_ys150428.fasta Fasta
ys151127_1008.msf Msf
ys151127_1008.raw Raw
ys151127_1103.msf Msf
ys151127_1103.raw Raw
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Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-arbovirus interference phenomenon.

Saucereau Yoann Y   Valiente Moro Claire C   Dieryckx Cindy C   Dupuy Jean-William JW   Tran Florence-Hélène FH   Girard Vincent V   Potier Patrick P   Mavingui Patrick P  

BMC genomics 20170818 1

<h4>Background</h4>Aedes albopictus is a vector of arboviruses that cause severe diseases in humans such as Chikungunya, Dengue and Zika fevers. The vector competence of Ae. albopictus varies depending on the mosquito population involved and the virus transmitted. Wolbachia infection status in believed to be among key elements that determine viral transmission efficiency. Little is known about the cellular functions mobilized in Ae. albopictus during co-infection by Wolbachia and a given arbovir  ...[more]

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