Proteomics

Dataset Information

0

Proteomic analysis of FBXL6 Knockdown cells proteome


ABSTRACT: FBXL6 is E3 ubiquitin ligase that we suspected to be involved in mitochondrial functions. We have investigated how deletion of this E3s by CRSIPR/Cas in Hela cells affects the cellular proteome. We compared this proteome to cells treated with CRISPR Non-Targeting Control (control cells).

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Dupuy Jean-William  

LAB HEAD: Giovanni Benard

PROVIDER: PXD037252 | Pride | 2023-09-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
F016979.dat Other
F016980.dat Other
F016981.dat Other
F016985.dat Other
F016986.dat Other
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Publications


In mammals, about 99% of mitochondrial proteins are synthesized in the cytosol as precursors that are subsequently imported into the organelle. The mitochondrial health and functions rely on an accurate quality control of these imported proteins. Here, we show that the E3 ubiquitin ligase F box/leucine-rich-repeat protein 6 (FBXL6) regulates the quality of cytosolically translated mitochondrial proteins. Indeed, we found that FBXL6 substrates are newly synthesized mitochondrial ribosomal protein  ...[more]

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