Dataset Information

Delineating changing partners of Akt1 protein as a function of its active state in HEK-293 Cells

ABSTRACT: Akt1 is a multi-functional protein, implicated and activated in multiple human solid tumors. Functional diversity of Akt1 is a result of its interactions with other proteins; which changes with changing context. This study was designed to capture the dynamics of Akt1 Interactome as a function of its active state. This could help us comprehend the indigenous composition of Akt1 interactome and how it changes as a function of inhibition of its active form.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Shweta Duggal

LAB HEAD: Dr. Kanury V.S. Rao

PROVIDER: PXD005976 | Pride | 2017-03-02

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Akt-Mk1-Ha1-lysc-0-0.group	Other
	Akt-Mk1-Ha1-lysc-8-10.group	Other
	Akt-Mk1-Ha1-tryp-0-0.group	Other
	Akt-Mk1-Ha1-tryp-8-10.group	Other
	Akt-Mk1-Ha1.wiff	Wiff

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Dataset to delineate changes in association between Akt1 and its interacting partners as a function of active state of Akt1 protein.

Gupta Nutan N Duggal Shweta S Jailkhani Noor N Chatterjee Samrat S Rao Kanury V S KVS Kumar Ajay A

Data in brief 20170525

Akt1 is a multi-functional protein, implicated in multiple human solid tumors. Pertaining to its key role in cell survival, Akt1 is under focus for development of targeted therapies. Functional diversity of Akt1 is a result of its interactions with other proteins; which changes with changing context. This investigation was designed to capture the dynamics of Akt1 Interactome as a function of its active state. Delineating dynamic changes in association of Akt1 with its interactors could help us c ...[more]

PMID: 28603765

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