Dataset Information
HIV-Tat treatment of human neurons in vitro over time: towards a model for the molecular pathology of HIV-associated neurocognitive disorders (~70% cell culture confluence dataset)
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neural Stem Cell Line, Neuron, Cell Culture, Embryonic Stem Cell
DISEASE(S): Human Immunodeficiency Virus Infectious Disease
SUBMITTER: 
Kim Gurwitz
LAB HEAD: Prof. Jonathan Blackburn
PROVIDER: PXD006332 | Pride | 2017-05-19
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 150123_Kim_T1BME1_200ngul.raw | Raw | |||
| 150123_Kim_T1BME2_200ngul.raw | Raw | |||
| 150123_Kim_T1BME3_200ngul.raw | Raw | |||
| 150123_Kim_T1BME4_200ngul.raw | Raw | |||
| 150123_Kim_T1TAT1_200ngul_150124011609.raw | Raw |
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Publications
Time-Dependent, HIV-Tat-Induced Perturbation of Human Neurons <i>In Vitro</i>: Towards a Model for the Molecular Pathology of HIV-Associated Neurocognitive Disorders.
Frontiers in molecular neuroscience 20170529
A significant proportion of human immunodeficiency virus type 1 (HIV)-positive individuals are affected by the cognitive, motor and behavioral dysfunction that characterizes HIV-associated neurocognitive disorders (HAND). While the molecular etiology of HAND remains largely uncharacterized, HIV transactivator of transcription (HIV-Tat) is thought to be an important etiological cause. Here we have used mass spectrometry (MS)-based discovery proteomics to identify the quantitative, cell-wide chang ...[more]
