Proteomics

Dataset Information

0

Label-free quantitative proteomic analysis of Mycobacterium avium hominissuis


ABSTRACT: The objective of this study is to investigate the protein expression level difference between Mycobacterium avium hominissuis wild type strain MAH-104 , its mutant 21m (gene lysX (MAV_3128) mutated - Lysyl tRNA synthetase) and the complemented strain 21c (MAV_3128comp) using liquid chromatography-mass spectrometry (LC/MS) based label free quantitative proteomics analysis.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mycobacterium Avium Complex Mycobacterium Avium Subsp. Hominissuis

SUBMITTER: Jayaseelan Murugaiyan  

LAB HEAD: Jayaseelan Murugaiyan

PROVIDER: PXD006470 | Pride | 2018-02-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MSrawfiledetails.xlsx Xlsx
MaxQuantResultfile.zip Other
P1C_01.raw Raw
P1C_02.raw Raw
P1C_03.raw Raw
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Publications

Proteome Analysis of a M. avium Mutant Exposes a Novel Role of the Bifunctional Protein LysX in the Regulation of Metabolic Activity.

Kirubakar Greana G   Murugaiyan Jayaseelan J   Schaudinn Christoph C   Dematheis Flavia F   Holland Gudrun G   Eravci Murat M   Weise Christoph C   Roesler Uwe U   Lewin Astrid A  

The Journal of infectious diseases 20180601 2


Lysyl-phosphatidylglycerol is one of the components of the mycobacterial membrane that contributes to the resistance to cationic antimicrobial peptides, a host-induced frontline defense against invading pathogens. Its production is catalyzed by LysX, a bifunctional protein with lysyl transferase and lysyl transfer RNA synthetase activity. Comparative proteome analysis of a lysX mutant of Mycobacterium avium strain 104 and the wild type indicated that the lysX mutant strain undergoes a transition  ...[more]

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