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HEK293 CD63 CRISPR cell-derived small EVs

ABSTRACT: The tetraspanin protein CD63 has been recently described as a key factor in extracellular vesicle (EV) production and endosomal cargo sorting. In this study, we assemble a global scope of CD63-dependent protein trafficking into small secreted vesicles.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Early Embryonic Cell

SUBMITTER: Stephanie Hurwitz

LAB HEAD: David Meckes, Jr.

PROVIDER: PXD006514 | Pride | 2018-10-24

REPOSITORIES: Pride

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Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1

Hurwitz Stephanie N SN Cheerathodi Mujeeb R MR Nkosi Dingani D York Sara B SB Meckes David G DG

Journal of virology 20180212 5

The tetraspanin protein CD63 has been recently described as a key factor in extracellular vesicle (EV) production and endosomal cargo sorting. In the context of Epstein-Barr virus (EBV) infection, CD63 is required for the efficient packaging of the major viral oncoprotein latent membrane protein 1 (LMP1) into exosomes and other EV populations and acts as a negative regulator of LMP1 intracellular signaling. Accumulating evidence has also pointed to intersections of the endosomal and autophagy pa ...[more]

PMID: 29212935

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